Non-Classical Androgen Actions

Abstract

Androgens (male sex hormones) are important for growth-maintenance of muscle and bone. The classical action of androgens is to bind the androgen receptor (AR) and regulate target genes. They can also act via non-classical AR mechanisms through other cellular pathways. To understand the role of non-classical actions in the musculoskeletal system we will study mice in which androgens can only act via this pathway. This knowledge is important for the treatment of osteoporosis and muscle wasting.

Related publications (1)

A physiological role for androgen actions in the absence of androgen receptor DNA binding activity

TPS Pang, MV Clarke, A Ghasem-Zadeh, NKL Lee, RA Davey, HE MacLean

2012-01-02

We tested the hypothesis that androgens have physiological actions via non-DNA binding-dependent androgen receptor (AR) signaling ..